In 12 healthy male subjects who received two doses of 100 mg cyclosporine capsule orally 12 hours apart with a single dose of 0
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The cyclosporine-treated patients showed significant decreases in GFR, creatinine clearance, and urea clearance, and increases in blood urea nitrogen (BUN) and percent urea reabsorption after intravascular volume depletion; these findings resolved after
Cyclosporine capsules and cyclosporine solution
The patient's BUN creatinine ratio, magnesium levels, and blood pressure require monitoring while on therapy
Cyclosporine is
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Relative leukopenia, lymphopenia, neutropenia and eosinopenia, although with values still within normal reference intervals, have all been observed
Common side effects of cyclosporine include: High blood pressure
Coadministration of telaprevir (750 mg every 8 hours for 11 days) with cyclosporine (10 mg on day 8) in healthy subjects resulted in increases in the mean dose-normalized AUC and C max of cyclosporine approximately 4
The nurse reviews this patient's laboratory results and notes a sharp increase in the blood urea nitrogen (BUN) and serum creatinine
The nurse reviews this patient's laboratory results and notes a sharp increase in the blood urea nitrogen (BUN) and serum creatinine
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burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
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Mea- surement of urea clearance during mild volume deple- tion confirmed that cyclosporine-treated patients had a reduced urea clearance not observed in the azathio- prine-treated
Kidney biopsies from 86 psoriasis patients treated for a mean duration of 23 months with 1
The pattern of injury that defines acute tubular necrosis includes renal tubular cell damage and death
Several commonly used chemotherapy drugs such as cisplatin, carboplatin, methotrexate and mitomycin can cause creatinine increases
2 to 7
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5 mg/kg/day of cyclosporine in two divided doses was administered orally
Protein breakdown is stimulated by hormones (such as glucagon, epinephrine, and cortisol) and inflammatory
An increase in serum creatinine and BUN may occur during Neoral therapy and reflect a reduction in the glomerular filtration rate
3-fold, respectively, compared to when cyclosporine (100 mg single dose) was given alone
Vital signs are normal, and the patient reports no discomfort