Guidelines for the administration of Phenytoin Intensive Care Unit Raigmore Hospital Directions for administration -Phenytoin injection should be injected
A medication administration route is often classified by the location at which the drug is administered, such as oral or intravenous
Guideline For Paediatric Patients, refer to the
Routes of administration: Oral and IV: Absorption: 50-90% bioavailability; erratic absorption because poor solubility in stomach acid and intestinal fluids
An intramuscular (IM) route formulation is also available for adults, not recommended for the neonatal or pediatric population
The first and most important intervention is to stagger the administration of phenytoin to separate it as much as possible from the tube feedings
route of administration based on bioavailability, safety and efficacy data
The choice of routes in which the medication is given depends not only on convenience and compliance but also on the drug’s pharmacokinetics and pharmacodynamic profile
1 Likewise, rectal absorption is not reliable
Which route of administration should the nurse use to provide the most effective continuous analgesia?, A client is prescribed a cholinesterase inhibitor, and a family member asks the nurse how this medication works
Serum levels of phenytoin in the therapeutic range cannot be rapidly achieved by this method
Phenytoin sodium capsules are approximately 90% bioavailable by the oral route
Acute administration of the anticonvulsant drug, phenytoin (PHT) has been shown to result in embryotoxicity and teratogenicity in several strains of mice
Panel 2: Techniques for administering drugs via enteral feeding tubes 23
The drop is caused by slower absorption, as compared to oral administration, because of the poor water solubility of phenytoin
One of the most poorly understood and potentially serious local complications of intravenous phenytoin administration is the purple glove syndrome, which is characterized by progressive limb edema, discoloration, and pain
Q Phenytoin is an anti-seizure medication with numerous pharmacokinetic considerations and drug interactions
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Specific patient characteristics are defined to guide administration and monitoring of parenteral phenytoin therapy
Administration of phenytoin so-dium in a liquid diet caused thymic and generalized lymphoma in females, and administration by intraperitoneal injection caused leuke-mia and thymic and mesenteric lymphoma in both sexes (IARC
Common Dilantin side effects may include: drowsiness, confusion; slurred speech; abnormal eye movement; or
A nurse is preparing to administer phenytoin suspension 300 mg PO, twice per day